| 1 | Iron Man 2 (2010) | $128M | $128M | |
| 2 | A Nightmare on Elm Street (2010) | $9.12M | $48.5M | |
| 3 | How to Train Your Dragon (2010) | $6.68M | $201M | |
| 4 | Date Night (2010) | $5.45M | $81M | |
| 5 | The Back-up Plan (2010) | $5.03M | $30.1M | |
| 6 | Furry Vengeance (2010) | $4.48M | $12.1M | |
| 7 | Clash of the Titans (2010) | $2.5M | $158M | |
| 8 | Death at a Funeral (2010) | $2.31M | $38.5M | |
| 9 | Bébé(s) (2010) | $2.16M | $2.16M | |
| 10 | The Losers (2010/I) | $1.85M | $21.5M |