| 1 | Alice in Wonderland (2010) | $116M | $116M | |
| 2 | Brooklyn's Finest (2009) | $13.4M | $13.4M | |
| 3 | Shutter Island (2010) | $13.2M | $95.8M | |
| 4 | Cop Out (2010) | $9.29M | $32.5M | |
| 5 | Avatar (2009) | $8.12M | $721M | |
| 6 | The Crazies (2010) | $7.08M | $27.5M | |
| 7 | Percy Jackson & the Olympians: The Lightning Thief (2010) | $5.12M | $78.1M | |
| 8 | Valentine's Day (2010) | $4.15M | $106M | |
| 9 | Crazy Heart (2009) | $3.31M | $29.5M | |
| 10 | Dear John (2010/I) | $2.78M | $76.6M |