| 1 | Shutter Island (2010) | $22.7M | $75.5M | |
| 2 | Cop Out (2010) | $18.2M | $18.2M | |
| 3 | The Crazies (2010) | $16.1M | $16.1M | |
| 4 | Avatar (2009) | $13.7M | $707M | |
| 5 | Percy Jackson & the Olympians: The Lightning Thief (2010) | $9.58M | $71M | |
| 6 | Valentine's Day (2010) | $9.06M | $99.9M | |
| 7 | Dear John (2010/I) | $4.81M | $72.4M | |
| 8 | The Wolfman (2010) | $4.26M | $57.4M | |
| 9 | Tooth Fairy (2010) | $3.43M | $53.8M | |
| 10 | Crazy Heart (2009) | $2.46M | $25M |